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APP | Amyloid Precursor Protein (N-term)

AS20 4455 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human, mouse, rat

APP | Amyloid Precursor Protein (N-term) in the group Antibodies for Human/Animal  / Human Proteins / Amyloid disorders / Alzheimer's disease at Agrisera AB (Antibodies for research) (AS20 4455)

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Product Information

Immunogen

Synthetic peptide (aa 653-662 of human APP) or 1-10 of the 4kDa Amyloid- peptide. The 4 kDa amyloid peptide is a 40 amino acid sequence that is cleaved of from the human amyloid A4 protein precursor (APP) and therefore the amino acids 1-10 of the peptide correspond to amino acids 653-662 of APP.

Host Rabbit
Clonality Polyclonal
Purity Affinity purified
Format Liquid in PBS containing 0.02% sodium azide as a preservative.
Quantity 100 µg
Storage Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tubes.
Tested applications Western blot (WB)
Recommended dilution Optimal concentration should be evaluated by serial dilutions. Detects APP and Ab peptide by Western blot at 0.5 to 1 µg/ml.

Reactivity

Confirmed reactivity Human, mouse, rat

Application examples

Additional information

Additional information Detects an approximately 120 kDa band in human, mouse and rat brain tissue lysates.

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Background

Background APP is an integral membrane protein found in many tissues and concentrated in the synapses of neurons. It is known as the precursor molecule generating amyloid beta (Aβ), and the amyloid fibrillar form is the primary component of amyloid plaques found in the brains of patients with Alzheimer's disease.

Product citations

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