APP | Amyloid Precursor Protein (N-term)
AS20 4455 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human, mouse, rat
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Immunogen Synthetic peptide (aa 653-662 of human APP) or 1-10 of the 4kDa Amyloid- peptide, The 4 kDa amyloid peptide is a 40 amino acid sequence that is cleaved of from the human amyloid A4 protein precursor (APP) and therefore the amino acids 1-10 of the peptide correspond to amino acids 653-662 of APP,
Purity Immunogen affinity purified in PBS. Contains 0.02% sodium azide.
Quantity 100 ĩg
Storage Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications Western blot (WB)
Recommended dilution Optimal concentration should be evaluated by serial dilutions, Detects APP and Ab peptide by Western blot at 0,5 to 1 ĩg/ml
Confirmed reactivity Human, mouse, rat
Additional information Detects an approximately 120 kDa band in human, mouse and rat brain tissue lysates
Background APP is an integral membrane protein found in many tissues and concentrated in the synapses of neurons. It is known as the precursor molecule generating amyloid beta (Aβ), and the amyloid fibrillar form is the primary component of amyloid plaques found in the brains of patients with Alzheimer's disease.
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