APP | Amyloid Precursor Protein (N-term)

Name: APP | Amyloid Precursor Protein (N-term)
Brand: IKP
SKU: AS20 4455
Price: 538 EUR
Availability: InStock

AS20 4455 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human, mouse, rat

APP | Amyloid Precursor Protein (N-term) in the group Antibodies Human Cell Biology / Neuroscience / Neurodegenerative diseases / Alzheimer's disease at Agrisera AB (Antibodies for research) (AS20 4455)

Product Information

Immunogen Synthetic peptide (aa 653-662 of human APP) or 1-10 of the 4kDa Amyloid- peptide, The 4 kDa amyloid peptide is a 40 amino acid sequence that is cleaved of from the human amyloid A4 protein precursor (APP) and therefore the amino acids 1-10 of the peptide correspond to amino acids 653-662 of APP,

Host Rabbit

Clonality Polyclonal

Purity Immunogen affinity purified in PBS. Contains 0.02% sodium azide.

Format Liquid

Quantity 100 µg

Storage Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Tested applications Western blot (WB)

Recommended dilution Optimal concentration should be evaluated by serial dilutions, Detects APP and Ab peptide by Western blot at 0,5 to 1 µg/ml

Reactivity

Confirmed reactivity Human, mouse, rat

Application examples

Additional information

Additional information Detects an approximately 120 kDa band in human, mouse and rat brain tissue lysates

Background

Background APP is an integral membrane protein found in many tissues and concentrated in the synapses of neurons. It is known as the precursor molecule generating amyloid beta (Aβ), and the amyloid fibrillar form is the primary component of amyloid plaques found in the brains of patients with Alzheimer's disease.

Product citations

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immunogen:	Synthetic peptide (aa 653-662 of human APP) or 1-10 of the 4kDa Amyloid- peptide, The 4 kDa amyloid peptide is a 40 amino acid sequence that is cleaved of from the human amyloid A4 protein precursor (APP) and therefore the amino acids 1-10 of the peptide correspond to amino acids 653-662 of APP,
Host:	Rabbit
Clonality:	Polyclonal
Purity:	Immunogen affinity purified in PBS. Contains 0.02% sodium azide.
Format:	Liquid
Quantity:	100 µg
storage:	Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications:	Western blot (WB)
recommended dilution:	Optimal concentration should be evaluated by serial dilutions, Detects APP and Ab peptide by Western blot at 0,5 to 1 µg/ml
Confirmed reactivity:	Human, mouse, rat
additional information:	Detects an approximately 120 kDa band in human, mouse and rat brain tissue lysates
background:	APP is an integral membrane protein found in many tissues and concentrated in the synapses of neurons. It is known as the precursor molecule generating amyloid beta (Aβ), and the amyloid fibrillar form is the primary component of amyloid plaques found in the brains of patients with Alzheimer's disease.